Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, Huang AJW, Liu Q. Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem. Cell. 2021 Jul 8;184(14):3762-3773.e10. doi: 10.1016/j.cell.2021.05.017. Epub 2021 Jun 15. PMID: 34133943.


Guo CJ, Mack MR, Oetjen LK, Trier AM, Council ML, Pavel AB, Guttman-Yassky E, Kim BS, Liu Q. Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation. J Invest Dermatol. 2020 Jun;140(6):1244-1252.e4. doi: 10.1016/j.jid.2019.10.022. Epub 2019 Dec 26. PMID: 31883963; PMCID: PMC7247952.


Li, F., Yang, W., Jiang, H., Guo, C., Huang, A., Hu, H., Qin, L. TRPV1 activity and substance P release are required for corneal cold nociceptionNat Commun 10, 5678 (2019) doi:10.1038/s41467-019-13536-0


Espino SS, Robinson SD, Safavi-Hemami H, Gajewiak J, Yang W, Olivera BM, Liu Q. Conopeptides promote itch through human itch receptor hMgprX1. Toxicon. 2018 Nov;154:28-34. doi: 10.1016/j.toxicon.2018.09.002. Epub 2018 Sep 21. PubMed PMID: 30243794.

Huang CC, Yang W, Guo C, Jiang H, Li F, Xiao M, Davidson S, Yu G, Duan B, Huang T, Huang AJW, Liu Q. Anatomical and functional dichotomy of ocular itch and pain. Nat Med. 2018 Aug;24(8):1268-1276. doi: 10.1038/s41591-018-0083-x. Epub 2018 Jul 9. PMID: 29988128; PMCID: PMC6093777.

Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O’Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q*, Hu H* (* co-corresponding) Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. The Journal of allergy and clinical immunology. 2018; 141(2):608-619.e7. NIHMSID: NIHMS892965 PubMed [journal] PMID: 28807414, PMCID: PMC5799031


Zhu Y, Hanson CE, Liu Q, Han L. Mrgprs activation is required for chronic itch conditions in mice. Itch (Philadelphia, Pa.). 2017; 2(3). NIHMSID: NIHMS904967 PubMed [journal] PMID: 29577089, PMCID: PMC5860675

Dong P, Guo C, Huang S, Ma M, Liu Q*, Luo W* (* co-corresponding). TRPC3 Is Dispensable for β-Alanine Triggered Acute Itch. Scientific reports. 2017; 7(1):13869. PubMed [journal]PMID: 29066740, PMCID: PMC5654773

Yang JM, Li F, Liu Q, Rüedi M, Wei ET, Lentsman M, Lee HS, Choi W, Kim SJ, Yoon KC. A novel TRPM8 agonist relieves dry eye discomfort. BMC ophthalmology. 2017;17(1):101. PubMed [journal] PMID: 28651550, PMCID: PMC5485613

Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Neuron. 2017; 93(4):840-853.e5.NIHMSID: NIHMS845486 PubMed [journal] PMID: 28231466, PMCID: PMC5324710

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell. 2017 Sep 21;171(1):217-228.e13. doi: 10.1016/j.cell.2017.08.006. Epub 2017 Sep 7. PMID: 28890086; PMCID: PMC5658016.


Yu G, Yang N, Li F, Chen M, Guo CJ, Wang C, Hu D, Yang Y, Zhu C, Wang Z, Shi H, Gegen T, Tang M, He Q, Liu Q* , Tang Z* (* co-corresponding). Enhanced itch elicited by capsaicin in a chronic itch model. Molecular pain. 2016; 12. PubMed [journal] PMID: 27118771,PMCID: PMC4956172

Tang M, Wu G, Wang Z, Yang N, Shi H, He Q, Zhu C, Yang Y, Yu G, Wang C, Yuan X, Liu Q, Guan Y, Dong X, Tang Z. Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons. Brain research. 2016; 1636:161-171. PubMed [journal] PMID: 26874069


Huang CC, Kim YS, Olson WP, Li F, Guo C, Luo W, Huang AJ, Liu Q. A histamine-independent itch pathway is required for allergic ocular itch. J Allergy Clin Immunol. 2015 Oct 28. pii: S0091-6749(15)01343-3. doi: 10.1016/j.jaci.2015.08.047. [Epub ahead of print] PubMed PMID: 26521042.

Wang C, Wang Z, Yang Y, Zhu C, Wu G, Yu G, Jian T, Yang N, Shi H, Tang M, He Q, Lan L, Liu Q, Guan Y, Dong X, Duan J, Tang Z. Pirt contributes to uterine contraction-induced pain in mice. Mol Pain. 2015 Sep 17;11:57. doi: 10.1186/s12990-015-0054-x. PubMed PMID: 26376721; PubMed Central PMCID: PMC4574137.

Li F, Guo CJ, Huang CC, Yu G, Brown SM, Xu S, Liu Q. Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice. Anesthesiology. 2015 Apr;122(4):768-75. doi: 10.1097/ALN.0000000000000607. PubMed PMID: 25646842.

Liu Q, Dong X. The role of the Mrgpr receptor family in itch. Handb Exp Pharmacol. 2015;226:71-88. doi: 10.1007/978-3-662-44605-8_5. Review. PubMed PMID: 25861775


Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T. Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem. 2014 Nov 1;22(21):5831-7. doi: 10.1016/j.bmc.2014.09.025. Epub 2014 Sep 19. PubMed PMID: 25288495; PubMed Central PMCID: PMC4254045.

Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain. 2014 Aug;155(8):1613-1621. doi: 10.1016/j.pain.2014.05.008. Epub 2014 May 9. PMID: 24813294; PMCID: PMC4104261.


He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic painPain. 2014 Mar;155(3):534-44. doi: 10.1016/j.pain.2013.12.008. Epub 2013 Dec 11. PubMed PMID: 24333779; PubMed Central PMCID: PMC3945061.

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nat Neurosci. 2013 Feb;16(2):174-82. doi: 10.1038/nn.3289. Epub 2012 Dec 23. PMID: 23263443; PMCID: PMC3557753.


Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X. Mechanisms of itch evoked by β-alanine. J Neurosci. 2012 Oct 17;32(42):14532-7. doi: 10.1523/JNEUROSCI.3509-12.2012. PMID: 23077038; PMCID: PMC3491570.

Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, Liu Y, Gao YJ, Liu YC, Ma Q, Dong X, Ji RR. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest. 2012 Jun;122(6):2195-207. doi: 10.1172/JCI45414. Epub 2012 May 8. PMID: 22565312; PMCID: PMC3366391.


Liu Q, Weng HJ, Patel KN, Tang Z, Bai H, Steinhoff M, Dong X. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal. 2011 Jul 12;4(181):ra45. doi: 10.1126/scisignal.2001925. PMID: 21775281; PMCID: PMC3144551.

Patel KN, Liu Q, Meeker S, Undem BJ, Dong X. Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. PLoS One. 2011;6(5):e20559. doi: 10.1371/journal.pone.0020559. Epub 2011 May 31. PMID: 21655234; PMCID: PMC3105090.

Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci. 2011 May;14(5):595-602. doi: 10.1038/nn.2789. Epub 2011 Apr 3. PMID: 21460831; PMCID: PMC3181150.


Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15933-8. doi: 10.1073/pnas.1011221107. Epub 2010 Aug 19. PMID: 20724664; PMCID: PMC2936626.